| Gene Information | |
|---|---|
| Gene Name | RNASEH2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 312 |
| Protein Names | Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000136104 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q5TBB1 |
| Gene Card | RNASEH2B |
| Uniprot ID | Q5TBB1 |
| Pfam | PF09468; PF17745 |
| In ASD | no |
| Allosteric Prediction | no (-1.00882164) |
| Ortholog in Animals | Alpaca_ RNASEH2B ( ortholog_one2one ) Dog_ RNASEH2B ( ortholog_one2one ) GuineaPig_ RNASEH2B ( ortholog_one2one ) Macaque_ RNASEH2B ( ortholog_one2many ) Mouse_ Rnaseh2b ( ortholog_one2one ) Pig_ RNASEH2B ( ortholog_one2one ) Rat_ Rnaseh2b ( ortholog_one2one ) Rabbit_ RNASEH2B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:16845400}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.039539(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3P56 (X-ray 4.06A ) 3P87 (X-ray 2.99A ) 3PUF (X-ray 3.10A ) |
| DBSNP | rs79564863 rs75325951 rs78071087 rs76158094 rs77931005 rs78705382 rs76219783 rs75971463 rs79310911 rs75184679 rs77377571 rs74555752 rs77391331 rs768565639 |
| Subcellular location [CC] | Nucleus {ECO:0000305}. |
| Mouse PG classification | LPG |
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