| Gene Information | |
|---|---|
| Gene Name | STEAP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 459 |
| Protein Names | Metalloreductase STEAP4 (EC 1.16.1.9) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000127954 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q687X5 |
| Gene Card | STEAP4 |
| Uniprot ID | Q687X5 |
| Pfam | PF03807; PF01794 |
| In ASD | no |
| Allosteric Prediction | no (-0.322470354) |
| Ortholog in Animals | Alpaca_ STEAP4 ( ortholog_one2one ) Alpaca_ STEAP4 ( ortholog_one2many ) Dog_ STEAP4 ( ortholog_one2many ) GuineaPig_ STEAP4 ( ortholog_one2one ) Macaque_ STEAP4 ( ortholog_one2one ) Mouse_ Steap4 ( ortholog_one2one ) Pig_ STEAP4 ( ortholog_one2one ) Rat_ Steap4 ( ortholog_one2one ) Rabbit_ STEAP4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | STEAP1B, STEAP3, STEAP1, STEAP2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages. {ECO:0000269|PubMed:15897894, ECO:0000269|PubMed:16227996, ECO:0000269|PubMed:18381574, ECO:0000269|PubMed:18430367, ECO:0000269|PubMed:19289123, ECO:0000269|PubMed:19660107}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6HCY (EM 3.10A ) 6HD1 (EM 3.80A ) |
| DBSNP | rs1981529 rs34741656 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15897894, ECO:0000269|PubMed:18430367}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}. Golgi apparatus membrane {ECO:0000269|PubMed:15897894}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}. Early endosome membrane {ECO:0000269|PubMed:15897894}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}. |
| Mouse PG classification | NA |
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