| Gene Information | |
|---|---|
| Gene Name | AMOT |
| Organism | Homo sapiens (Human) |
| Gene Length | 1084 |
| Protein Names | Angiomotin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000126016 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q4VCS5 |
| Gene Card | AMOT |
| Uniprot ID | Q4VCS5 |
| Pfam | PF12240 |
| In ASD | no |
| Allosteric Prediction | no (-0.384455469) |
| Ortholog in Animals | Alpaca_ AMOT ( ortholog_one2one ) Dog_ AMOT ( ortholog_one2one ) GuineaPig_ AMOT ( ortholog_one2one ) Macaque_ AMOT ( ortholog_one2one ) Mouse_ Amot ( ortholog_one2one ) Pig_ AMOT ( ortholog_one2one ) Rat_ Amot ( ortholog_one2one ) Rabbit_ AMOT ( ortholog_one2one ) |
| Ohnologs | AMOTL2, AMOTL1 |
| Paralogs | AMOTL1, AMOTL2 |
| Tissue | NA |
| Tissue Specificity | Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta. {ECO:0000269|PubMed:11257124}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.012903(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6JJX (X-ray 2.00A ) 7LP2 (X-ray 1.88A ) 7LP3 (X-ray 1.61A ) 7LP5 (NMR - ) 7NMA (X-ray 1.75A ) 7NMW (X-ray 1.50A ) 7NMX (X-ray 2.30A ) 7NN2 (X-ray 1.80A ) 7NND (X-ray 1.40A ) 7NNE (X-ray 1.96A ) 7NP2 (X-ray 1.27A ) 7NPB (X-ray 1.37A ) 7NPG (X-ray 1.37A ) 7OQG (X-ray 1.50A ) 7OQJ (X-ray 1.40A ) 7OQS (X-ray 1.34A ) 7OQU (X-ray 1.40A ) 7OQW (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell junction, tight junction {ECO:0000269|PubMed:16043488}. Note=Localized on the cell surface. May act as a transmembrane protein. |
| Mouse PG classification | NA |
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