Gene Information
Gene NameAMBP
OrganismHomo sapiens (Human)
Gene Length352
Protein NamesProtein AMBP (Protein HC) [Cleaved into: Alpha-1-microglobulin (EC 1.6.2.-) (Alpha-1 microglycoprotein) (Complex-forming glycoprotein heterogeneous in charge); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (EDC1) (HI-30) (Uronic-acid-rich protein); Trypstatin]
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000106927 )
Evolutionary StageEumetazoa
AlphaFoldDBP02760
Gene CardAMBP
Uniprot IDP02760
PfamPF00014; PF00061
In ASDno
Allosteric Predictionyes (0.773883546)
Ortholog in AnimalsAlpaca_ AMBP ( ortholog_one2one )
Dog_ AMBP ( ortholog_one2one )
GuineaPig_ AMBP ( ortholog_one2one )
Macaque_ AMBP ( ortholog_one2one )
Mouse_ Ambp ( ortholog_one2one )
Pig_ AMBP ( ortholog_one2one )
Rat_ Ambp ( ortholog_one2one )
OhnologsNA
ParalogsSPINT4, EPPIN, WFIKKN1, KIAA0319, TFPI, SPINT1, TFPI2, SPINT2, WFIKKN2, WFDC8, LRP11, KIAA0319L, WFDC6
Tissueliver
Tissue Specificity[Alpha-1-microglobulin]: Expressed by the liver and secreted in plasma. Occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid (PubMed:11877257). Expressed in epidermal keratinocytes, in dermis and epidermal-dermal junction (at protein level) (PubMed:22096585). Expressed in red blood cells (at protein level) (PubMed:32092412). Expressed in placenta (PubMed:21356557). {ECO:0000269|PubMed:11877257, ECO:0000269|PubMed:21356557, ECO:0000269|PubMed:22096585, ECO:0000269|PubMed:32092412}.;
[Inter-alpha-trypsin inhibitor light chain]: Expressed in airway epithelium and submucosal gland (at protein level). Colocalizes with TNFAIP6 at the ciliary border. Present in bronchoalveolar lavage fluid (at protein level). {ECO:0000269|PubMed:16873769}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1BIK  (X-ray  2.50A  )  3QKG  (X-ray  2.30A  )  4ES7  (X-ray  2.00A  )  4U30  (X-ray  2.50A  )  6EJ7  (X-ray  2.00A  )  6EJ8  (X-ray  2.09A  )  6EJ9  (X-ray  2.02A  )  6EJA  (X-ray  1.94A  )  6EJB  (X-ray  2.56A  )  6EJC  (X-ray  2.06A  )  6EJD  (X-ray  2.68A  ) 
DBSNP NA 
Subcellular location [CC][Alpha-1-microglobulin]: Secreted {ECO:0000269|PubMed:11877257, ECO:0000269|PubMed:32092412}. Endoplasmic reticulum {ECO:0000269|PubMed:22096585}. Cytoplasm, cytosol {ECO:0000269|PubMed:32092412}. Cell membrane {ECO:0000269|PubMed:22096585, ECO:0000269|PubMed:32092412};
Peripheral membrane protein {ECO:0000305|PubMed:22096585, ECO:0000305|PubMed:32092412}. Nucleus membrane {ECO:0000269|PubMed:22096585};
Peripheral membrane protein {ECO:0000305|PubMed:22096585}. Mitochondrion inner membrane {ECO:0000305|PubMed:23157686};
Peripheral membrane protein {ECO:0000305|PubMed:23157686}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:22096585}. Note=The cellular uptake occurs via a non-endocytotic pathway and allows for localization to various membrane structures. A specific binding to plasma membrane suggests the presence of a cell receptor, yet to be identified. Directly binds collagen fibers type I. {ECO:0000269|PubMed:22096585}.
Mouse PG classificationNA
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