| Gene Information | |
|---|---|
| Gene Name | WASF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 559 |
| Protein Names | Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000112290 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92558 |
| Gene Card | WASF1 |
| Uniprot ID | Q92558 |
| Pfam | PF02205 |
| In ASD | no |
| Allosteric Prediction | no (-0.330549488) |
| Ortholog in Animals | Alpaca_ WASF1 ( ortholog_one2one ) Dog_ WASF1 ( ortholog_one2one ) GuineaPig_ WASF1 ( ortholog_one2one ) Macaque_ WASF1 ( ortholog_one2one ) Mouse_ Wasf1 ( ortholog_one2one ) Rat_ Wasf1 ( ortholog_one2one ) Rabbit_ WASF1 ( ortholog_one2one ) |
| Ohnologs | WASF3, WASF4P, WASF2 |
| Paralogs | WASF2, WASF3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.289209(Rat);0.030769(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3P8C (X-ray 2.29A ) 4N78 (X-ray 2.43A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9889097}. Synapse {ECO:0000250|UniProtKB:Q5BJU7}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097). Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503). In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9889097}. |
| Mouse PG classification | NA |
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