Gene Information
Gene NameALPL
OrganismHomo sapiens (Human)
Gene Length524
Protein NamesAlkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNS-ALP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1)
Target Namealkaline phosphatase tissue-nonspecific
Target TypeSuccessful target
Gene Age1488 ( ENSG00000162551 )
Evolutionary StageCellular_organisms
AlphaFoldDBP05186
Gene CardALPL
Uniprot IDP05186
PfamPF00245
In ASDno
Allosteric Predictionyes (0.190116501)
Ortholog in AnimalsAlpaca_ ALPL ( ortholog_one2one )
Dog_ ALPL ( ortholog_one2one )
GuineaPig_ ALPL ( ortholog_one2one )
Macaque_ ALPL ( ortholog_one2one )
Mouse_ Alpl ( ortholog_one2one )
Pig_ ALPL ( ortholog_one2one )
Rat_ Alpl ( ortholog_one2one )
Rabbit_ ALPL ( ortholog_one2one )
OhnologsALPP, ALPG, ALPI
ParalogsALPG, ALPI, ALPP
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs121918005  rs770093969  rs1470389268  rs121918001  rs121918003  rs121918003  rs121918001  rs1304394441  rs1057521085  rs121918015  rs773257111  rs121918013  rs954135116  rs1159854007  rs786204530  rs780583917  rs121918011  rs1376937780  rs149344982  rs760029254  rs121918012  rs778232217  rs121918019  rs199669988  rs121918000  rs199590449  rs763159520  rs121918007  rs121918004  rs199665722  rs766076920  rs1226800998  rs1223142821  rs121918018  rs3200254  rs781272386  rs781272386  rs1237252052  rs786204473  rs765458125  rs121918002  rs1553414079  rs1220125702  rs121918017  rs763457259  rs121918010  rs121918009  rs1553414563  rs1553414568  rs121918008  rs771540767  rs371243939  rs1442918125  rs121918014  rs121918006  rs1553415041  rs138690664  rs150799088  rs966212736  rs121918016  rs1054159992  rs1196976671  rs1413274209  rs34605986 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:2220817, ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064, ECO:0000269|PubMed:33821301};
Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064}. Extracellular vesicle membrane {ECO:0000250|UniProtKB:P09242};
Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P09242}. Mitochondrion membrane {ECO:0000250|UniProtKB:P09242};
Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P09242}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P09242}. Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. Localizes to the mitochondria of thermogenic fat cells: tethered to mitochondrial membranes via a GPI-anchor and probably resides in the mitochondrion intermembrane space. {ECO:0000250|UniProtKB:P09242}.
Mouse PG classificationNA
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