| Gene Information | |
|---|---|
| Gene Name | ALPL |
| Organism | Homo sapiens (Human) |
| Gene Length | 524 |
| Protein Names | Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNS-ALP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1) |
| Target Name | alkaline phosphatase, tissue-nonspecific isozyme |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000162551 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P05186 |
| Gene Card | ALPL |
| Uniprot ID | P05186 |
| Pfam | PF00245 |
| In ASD | no |
| Allosteric Prediction | yes (0.190116501) |
| Ortholog in Animals | Alpaca_ ALPL ( ortholog_one2one ) Dog_ ALPL ( ortholog_one2one ) GuineaPig_ ALPL ( ortholog_one2one ) Macaque_ ALPL ( ortholog_one2one ) Mouse_ Alpl ( ortholog_one2one ) Pig_ ALPL ( ortholog_one2one ) Rat_ Alpl ( ortholog_one2one ) Rabbit_ ALPL ( ortholog_one2one ) |
| Ohnologs | ALPP, ALPG, ALPI |
| Paralogs | ALPG, ALPI, ALPP |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs121918005 rs770093969 rs1470389268 rs121918001 rs121918003 rs121918003 rs121918001 rs1304394441 rs1057521085 rs121918015 rs773257111 rs121918013 rs954135116 rs1159854007 rs786204530 rs780583917 rs121918011 rs1376937780 rs149344982 rs760029254 rs121918012 rs778232217 rs121918019 rs199669988 rs121918000 rs199590449 rs763159520 rs121918007 rs121918004 rs199665722 rs766076920 rs1226800998 rs1223142821 rs121918018 rs3200254 rs781272386 rs781272386 rs1237252052 rs786204473 rs765458125 rs121918002 rs1553414079 rs1220125702 rs121918017 rs763457259 rs121918010 rs121918009 rs1553414563 rs1553414568 rs121918008 rs771540767 rs371243939 rs1442918125 rs121918014 rs121918006 rs1553415041 rs138690664 rs150799088 rs966212736 rs121918016 rs1054159992 rs1196976671 rs1413274209 rs34605986 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:2220817, ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064, ECO:0000269|PubMed:33821301}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064}. Extracellular vesicle membrane {ECO:0000250|UniProtKB:P09242}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P09242}. Mitochondrion membrane {ECO:0000250|UniProtKB:P09242}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P09242}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P09242}. Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. Localizes to the mitochondria of thermogenic fat cells: tethered to mitochondrial membranes via a GPI-anchor and probably resides in the mitochondrion intermembrane space. {ECO:0000250|UniProtKB:P09242}. |
| Mouse PG classification | NA |
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