| Gene Information | |
|---|---|
| Gene Name | ALPK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1244 |
| Protein Names | Alpha-protein kinase 1 (EC 2.7.11.1) (Chromosome 4 kinase) (Lymphocyte alpha-protein kinase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000073331 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q96QP1 |
| Gene Card | ALPK1 |
| Uniprot ID | Q96QP1 |
| Pfam | PF02816 |
| In ASD | no |
| Allosteric Prediction | yes (0.248074151) |
| Ortholog in Animals | Alpaca_ ALPK1 ( ortholog_one2one ) Dog_ ALPK1 ( ortholog_one2one ) GuineaPig_ ALPK1 ( ortholog_one2one ) Macaque_ ALPK1 ( ortholog_one2one ) Mouse_ Alpk1 ( ortholog_one2one ) Pig_ ALPK1 ( ortholog_one2one ) Rat_ Alpk1 ( ortholog_one2one ) Rabbit_ ALPK1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HSPA12B, HSPA12A, ALPK2, EEF2K |
| Tissue | NA |
| Tissue Specificity | Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina (PubMed:30967659). {ECO:0000269|PubMed:10819331, ECO:0000269|PubMed:30967659}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5Z2C (X-ray 2.59A ) |
| DBSNP | rs33943680 rs6533616 rs34120296 rs757602009 rs147641444 rs2074388 rs13148353 rs35389530 rs35519493 rs2074379 rs11726117 rs2074380 rs34946272 rs35308602 rs2074381 rs34780600 rs34079946 rs34677416 rs35756863 rs55696324 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:30111836}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:30967659}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30967659}. Cell projection, cilium {ECO:0000269|PubMed:30967659}. Note=Localized at the base of primary cilia. {ECO:0000269|PubMed:30967659}. |
| Mouse PG classification | NA |
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