| Gene Information | |
|---|---|
| Gene Name | ALOX5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 674 |
| Protein Names | Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34) |
| Target Name | arachidonate 5-lipoxygenase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000012779 ) 3 ( ENSG00000275565 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P09917 |
| Gene Card | ALOX5 |
| Uniprot ID | P09917 |
| Pfam | PF00305; PF01477 |
| In ASD | yes |
| Allosteric Prediction | yes (1.076102675) |
| Ortholog in Animals | Alpaca_ ALOX5 ( ortholog_one2one ) Dog_ ALOX5 ( ortholog_one2one ) GuineaPig_ ALOX5 ( ortholog_one2one ) Macaque_ ALOX5 ( ortholog_one2one ) Mouse_ Alox5 ( ortholog_one2one ) Pig_ ALOX5 ( ortholog_one2one ) Rat_ Alox5 ( ortholog_one2one ) Rabbit_ ALOX5 ( ortholog_one2one ) |
| Ohnologs | ALOX12, ALOX15B |
| Paralogs | ALOX12, ALOX15, ALOXE3, ALOX15B, ALOX12B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3O8Y (X-ray 2.39A ) 3V92 (X-ray 2.74A ) 3V98 (X-ray 2.07A ) 3V99 (X-ray 2.25A ) 6N2W (X-ray 2.71A ) 6NCF (X-ray 2.87A ) 7TTJ (X-ray 2.10A ) 7TTL (X-ray 2.43A ) |
| DBSNP | rs2228065 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:P48999, ECO:0000269|PubMed:18978352}. Nucleus matrix {ECO:0000269|PubMed:19233132}. Nucleus membrane {ECO:0000269|PubMed:16275640}; Peripheral membrane protein {ECO:0000269|PubMed:16275640}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19022417}. Cytoplasm, cytosol {ECO:0000269|PubMed:19233132}. Nucleus envelope {ECO:0000269|PubMed:16275640, ECO:0000269|PubMed:19233132, ECO:0000269|PubMed:8245774}. Nucleus intermembrane space {ECO:0000269|PubMed:8245774}. Note=Shuttles between cytoplasm and nucleus (PubMed:19233132). Found exclusively in the nucleus, when phosphorylated on Ser-272 (PubMed:18978352). Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association (PubMed:19233132, PubMed:3118366, PubMed:8245774, PubMed:16275640). {ECO:0000269|PubMed:16275640, ECO:0000269|PubMed:18978352, ECO:0000269|PubMed:19233132, ECO:0000269|PubMed:3118366, ECO:0000269|PubMed:8245774}. |
| Mouse PG classification | NA |
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