| Gene Information | |
|---|---|
| Gene Name | ALOX15B |
| Organism | Homo sapiens (Human) |
| Gene Length | 676 |
| Protein Names | Polyunsaturated fatty acid lipoxygenase ALOX15B (15-lipoxygenase 2) (15-LOX-2) (Arachidonate 15-lipoxygenase B) (15-LOX-B) (EC 1.13.11.33) (Arachidonate 15-lipoxygenase type II) (Linoleate 13-lipoxygenase 15-LOb) (EC 1.13.11.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000179593 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O15296 |
| Gene Card | ALOX15B |
| Uniprot ID | O15296 |
| Pfam | PF00305; PF01477 |
| In ASD | yes |
| Allosteric Prediction | yes (0.654636466) |
| Ortholog in Animals | Alpaca_ ALOX15B ( ortholog_one2one ) Dog_ ALOX15B ( ortholog_one2one ) GuineaPig_ ALOX15B ( ortholog_one2one ) Mouse_ Alox8 ( ortholog_one2one ) Pig_ ALOX15B ( ortholog_one2one ) Rat_ Alox15b ( ortholog_one2one ) Rabbit_ ALOX15B ( ortholog_one2one ) |
| Ohnologs | ALOX5 |
| Paralogs | ALOX12, ALOX15, ALOXE3, ALOX5, ALOX12B |
| Tissue | prostate, lung |
| Tissue Specificity | Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea. {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:11350124, ECO:0000269|PubMed:9177185}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4NRE (X-ray 2.63A ) 7LAF (X-ray 2.44A ) |
| DBSNP | rs140152561 rs9895916 rs4792147 rs7225107 |
| Subcellular location [CC] | [Isoform A]: Nucleus {ECO:0000269|PubMed:12704195}. Note=Other isoforms are excluded from the nucleus. {ECO:0000269|PubMed:12704195}.; Cytoplasm, cytosol {ECO:0000269|PubMed:12704195}. Cell membrane {ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:27435673}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12704195}. Membrane {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:24497644}; Peripheral membrane protein {ECO:0000269|PubMed:24497644}. Cell junction, adherens junction {ECO:0000269|PubMed:12704195}. Cell junction, focal adhesion {ECO:0000269|PubMed:12704195}. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:24497644, ECO:0000269|PubMed:27435673}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |