| Gene Information | |
|---|---|
| Gene Name | RSPO3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 272 |
| Protein Names | R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) |
| Target Name | r-spondin-3 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000146374 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BXY4 |
| Gene Card | RSPO3 |
| Uniprot ID | Q9BXY4 |
| Pfam | PF15913 |
| In ASD | no |
| Allosteric Prediction | no (-0.924103132) |
| Ortholog in Animals | Alpaca_ RSPO3 ( ortholog_one2one ) Dog_ RSPO3 ( ortholog_one2one ) GuineaPig_ RSPO3 ( ortholog_one2one ) Macaque_ RSPO3 ( ortholog_one2one ) Mouse_ Rspo3 ( ortholog_one2one ) Pig_ RSPO3 ( ortholog_one2one ) Rat_ Rspo3 ( ortholog_one2one ) Rabbit_ RSPO3 ( ortholog_one2one ) |
| Ohnologs | RSPO2, RSPO1 |
| Paralogs | RSPO4, RSPO2, RSPO1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node (PubMed:12463421). Highly expressed in endothelial cells (PubMed:26766444). {ECO:0000269|PubMed:12463421, ECO:0000269|PubMed:26766444}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000250|UniProtKB:Q2TJ95}. |
| Mouse PG classification | NA |
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