| Gene Information | |
|---|---|
| Gene Name | ABCG8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 673 |
| Protein Names | ATP-binding cassette sub-family G member 8 (EC 7.6.2.-) (Sterolin-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000143921 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H221 |
| Gene Card | ABCG8 |
| Uniprot ID | Q9H221 |
| Pfam | PF01061; PF19055; PF00005 |
| In ASD | no |
| Allosteric Prediction | yes (0.89314433) |
| Ortholog in Animals | Alpaca_ ABCG8 ( ortholog_one2one ) Dog_ ABCG8 ( ortholog_one2one ) GuineaPig_ ABCG8 ( ortholog_one2one ) Macaque_ ABCG8 ( ortholog_one2one ) Mouse_ Abcg8 ( ortholog_one2one ) Pig_ ABCG8 ( ortholog_one2one ) Rat_ Abcg8 ( ortholog_one2one ) Rabbit_ ABCG8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ABCG5, ABCG4, ABCG1, ABCG2 |
| Tissue | duodenum, liver, small.intestine |
| Tissue Specificity | Predominantly expressed in the liver (PubMed:11099417, PubMed:11452359). Low expression levels in the small intestine and colon (PubMed:11099417). Very low levels in other tissues, including brain, heart and spleen (PubMed:11452359). {ECO:0000269|PubMed:11099417, ECO:0000269|PubMed:11452359}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5DO7 (X-ray 3.93A ) 7JR7 (EM 3.30A ) 7R87 (EM 3.40A ) 7R88 (EM 3.50A ) 7R89 (EM 2.60A ) 7R8A (EM 2.90A ) 7R8B (EM 3.10A ) 8CUB (X-ray 4.05A ) |
| DBSNP | rs11887534 rs4148211 rs766212636 rs9282574 rs137852993 rs34754243 rs35518570 rs137852990 rs4148217 rs1177309800 rs1233989408 rs201690654 rs769576789 rs1325979386 rs137852988 rs137852992 rs6544718 rs145125968 rs9282573 |
| Subcellular location [CC] | Cell membrane {ECO:0000305|PubMed:16893193}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}. Apical cell membrane {ECO:0000269|PubMed:14504269}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}. |
| Mouse PG classification | LPG |
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