| Gene Information | |
|---|---|
| Gene Name | ITGA6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1130 |
| Protein Names | Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000091409 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P23229 |
| Gene Card | ITGA6 |
| Uniprot ID | P23229 |
| Pfam | PF01839; PF08441 |
| In ASD | no |
| Allosteric Prediction | no (-0.155840469) |
| Ortholog in Animals | Alpaca_ ITGA6 ( ortholog_one2one ) Dog_ ITGA6 ( ortholog_one2one ) GuineaPig_ ITGA6 ( ortholog_one2one ) Macaque_ ITGA6 ( ortholog_one2one ) Mouse_ Itga6 ( ortholog_one2one ) Pig_ ITGA6 ( ortholog_one2one ) Rat_ Itga6 ( ortholog_one2one ) Rabbit_ ITGA6 ( ortholog_one2one ) |
| Ohnologs | ITGA3, ITGA7, ITGA9 |
| Paralogs | ITGA10, ITGA4, ITGAX, ITGAE, ITGA2, ITGAD, ITGA5, ITGAV, ITGA7, ITGA8, ITGAL, ITGA3, ITGA2B, ITGA11, ITGA1, ITGAM, ITGA9 |
| Tissue | NA |
| Tissue Specificity | Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Processed integrin alpha-6: Expressed at low levels in normal prostate tissue with elevated levels in prostate cancer tissue (at protein level) (PubMed:15023541). {ECO:0000269|PubMed:15023541, ECO:0000269|PubMed:7681434}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7CEB (X-ray 2.89A ) 7CEC (EM 3.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22314500}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:22314500}; Lipid-anchor {ECO:0000269|PubMed:22314500}. |
| Mouse PG classification | NA |
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