| Gene Information | |
|---|---|
| Gene Name | ALKAL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 129 |
| Protein Names | ALK and LTK ligand 1 (Augmentor beta) (AUG-beta) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000196711 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q6UXT8 |
| Gene Card | ALKAL1 |
| Uniprot ID | Q6UXT8 |
| Pfam | PF15129 |
| In ASD | no |
| Allosteric Prediction | no (-0.974492113) |
| Ortholog in Animals | Alpaca_ ALKAL1 ( ortholog_one2one ) Macaque_ ALKAL1 ( ortholog_one2one ) Mouse_ Alkal1 ( ortholog_one2one ) Pig_ ALKAL1 ( ortholog_one2one ) Rat_ Alkal1 ( ortholog_one2one ) Rabbit_ ALKAL1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in thyroid and moderate levels in stomach, trachea, small intestine, prostate and brain. {ECO:0000269|PubMed:25331893}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7MK7 (X-ray 2.43A ) 7MZZ (NMR - ) 7NX0 (X-ray 1.95A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000250|UniProtKB:Q6UX46}. Cell membrane {ECO:0000305|PubMed:34646012}. Note=Following interaction with receptor tyrosine kinase LTK, associates with the cell membrane, membrane-binding is required to activate LTK. {ECO:0000250|UniProtKB:Q6UX46}. |
| Mouse PG classification | NA |
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