| Gene Information | |
|---|---|
| Gene Name | ALK |
| Organism | Homo sapiens (Human) |
| Gene Length | 1620 |
| Protein Names | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) |
| Target Name | alk tyrosine kinase receptor |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000171094 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UM73 |
| Gene Card | ALK |
| Uniprot ID | Q9UM73 |
| Pfam | PF00629; PF07714 |
| In ASD | yes |
| Allosteric Prediction | yes (1.357890111) |
| Ortholog in Animals | Alpaca_ ALK ( ortholog_one2one ) Dog_ ALK ( ortholog_one2one ) GuineaPig_ ALK ( ortholog_one2one ) Macaque_ ALK ( ortholog_one2one ) Mouse_ Alk ( ortholog_one2one ) Rat_ Alk ( ortholog_one2one ) Rabbit_ ALK ( ortholog_one2one ) |
| Ohnologs | LTK |
| Paralogs | EPHA7, NTRK1, EPHB3, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells. {ECO:0000269|PubMed:9174053}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2KUP (NMR - ) 2KUQ (NMR - ) 2XB7 (X-ray 2.50A ) 2XBA (X-ray 1.95A ) 2XP2 (X-ray 1.90A ) 2YFX (X-ray 1.70A ) 2YHV (X-ray 1.90A ) 2YJR (X-ray 1.90A ) 2YJS (X-ray 1.90A ) 2YS5 (NMR - ) 2YT2 (NMR - ) 3AOX (X-ray 1.75A ) 3L9P (X-ray 1.80A ) 3LCS (X-ray 1.95A ) 3LCT (X-ray 2.10A ) 4ANL (X-ray 1.70A ) 4ANQ (X-ray 1.76A ) 4ANS (X-ray 1.85A ) 4CCB (X-ray 2.03A ) 4CCU (X-ray 2.00A ) 4CD0 (X-ray 2.23A ) 4CLI (X-ray 2.05A ) 4CLJ (X-ray 1.66A ) 4CMO (X-ray 2.05A ) 4CMT (X-ray 1.73A ) 4CMU (X-ray 1.80A ) 4CNH (X-ray 1.90A ) 4CTB (X-ray 1.79A ) 4CTC (X-ray 2.03A ) 4DCE (X-ray 2.03A ) 4FNW (X-ray 1.75A ) 4FNX (X-ray 1.70A ) 4FNY (X-ray 2.45A ) 4FNZ (X-ray 2.60A ) 4FOB (X-ray 1.90A ) 4FOC (X-ray 1.70A ) 4FOD (X-ray 2.00A ) 4JOA (X-ray 2.70A ) 4MKC (X-ray 2.01A ) 4TT7 (X-ray 2.10A ) 4Z55 (X-ray 1.55A ) 5A9U (X-ray 1.60A ) 5AA8 (X-ray 1.86A ) 5AA9 (X-ray 1.93A ) 5AAA (X-ray 1.73A ) 5AAB (X-ray 2.20A ) 5AAC (X-ray 1.70A ) 5FTO (X-ray 2.22A ) 5FTQ (X-ray 1.70A ) 5IMX (X-ray 2.12A ) 5IUG (X-ray 1.93A ) 5IUH (X-ray 2.10A ) 5IUI (X-ray 1.88A ) 5KZ0 (X-ray 2.30A ) 5VZ5 (X-ray 2.59A ) 6AT9 (X-ray 2.95A ) 6CDT (X-ray 1.80A ) 6E0R (X-ray 2.30A ) 6EBW (X-ray 2.46A ) 6EDL (X-ray 2.80A ) 6MX8 (X-ray 1.96A ) 7BTT (X-ray 1.86A ) 7JY4 (X-ray 2.42A ) 7JYR (X-ray 2.32A ) 7JYS (X-ray 2.22A ) 7JYT (X-ray 2.00A ) 7LRZ (X-ray 1.91A ) 7LS0 (X-ray 3.05A ) 7MZW (NMR - ) 7MZY (X-ray 1.50A ) 7N00 (EM 2.27A ) 7NWZ (X-ray 4.17A ) 7NX3 (X-ray 2.81A ) 7NX4 (X-ray 3.00A ) 7R7K (X-ray 1.83A ) 7R7R (X-ray 1.94A ) |
| DBSNP | rs34617074 rs55697431 rs56077855 rs35093491 rs35228363 rs34829159 rs55941323 rs746442213 rs35073634 rs864309584 rs55760835 rs113994088 rs113994091 rs1057520019 rs1057519698 rs1057519697 rs281864719 rs863225281 rs281864719 rs113994089 rs863225283 rs281864720 rs113994092 rs45502292 rs113994087 rs113994087 rs863225285 rs56160491 rs17694720 rs55782189 rs56181542 rs55906201 rs1670283 rs1881420 rs1881421 rs1881423 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:34819673, ECO:0000269|PubMed:9174053}; Single-pass type I membrane protein {ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:9174053}. Note=Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. {ECO:0000269|PubMed:16317043}. |
| Mouse PG classification | NA |
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