Gene Information
Gene NamePRTN3
OrganismHomo sapiens (Human)
Gene Length256
Protein NamesMyeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)
Target Nameleukocyte proteinase-3
Target TypeClinical trial target
Gene Age78 ( ENSG00000196415 )
3 ( ENSG00000277804 )
Evolutionary StageEumetazoa
AlphaFoldDBP24158
Gene CardPRTN3
Uniprot IDP24158
PfamPF00089
In ASDyes
Allosteric Predictionyes (0.999895632)
Ortholog in AnimalsAlpaca_ PRTN3 ( ortholog_one2one )
Macaque_ PRTN3 ( ortholog_one2one )
Mouse_ Prtn3 ( ortholog_one2one )
Pig_ PRTN3 ( ortholog_one2one )
Rat_ Prtn3 ( ortholog_one2one )
OhnologsNA
ParalogsELANE, CELA1, CELA3A, CELA3B, CELA2A, CELA2B
Tissuebone.marrow, spleen, whole.blood
Tissue SpecificityExpressed in polymorphonuclear leukocytes (at protein level) (PubMed:2033050, PubMed:7897245, PubMed:3198760). Expressed in neutrophils (at protein level) (PubMed:28240246, PubMed:18462208, PubMed:21193407, PubMed:22266279, PubMed:17244676). Expressed in differentiating neutrophils (PubMed:18462208). {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:2033050, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246, ECO:0000269|PubMed:3198760, ECO:0000269|PubMed:7897245}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1FUJ  (X-ray  2.20A  ) 
DBSNP rs351111  rs1042281  rs1042282 
Subcellular location [CC]Cytoplasmic granule {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:2033050, ECO:0000269|PubMed:3198760, ECO:0000269|PubMed:7897245, ECO:0000305|PubMed:17244676}. Secreted {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:28240246}. Cell membrane {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246};
Peripheral membrane protein {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246};
Extracellular side {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246}. Membrane raft {ECO:0000269|PubMed:21193407};
Peripheral membrane protein {ECO:0000269|PubMed:21193407};
Extracellular side {ECO:0000269|PubMed:21193407}. Note=Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:2033050, PubMed:3198760, PubMed:7897245, PubMed:18462208). Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246). Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279). {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:2033050, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246, ECO:0000269|PubMed:3198760, ECO:0000269|PubMed:7897245}.
Mouse PG classificationNA
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