| Gene Information | |
|---|---|
| Gene Name | ALG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 191 |
| Protein Names | Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000119523 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O75340 |
| Gene Card | PDCD6 |
| Uniprot ID | O75340 |
| Pfam | PF13202; PF13499 |
| In ASD | no |
| Allosteric Prediction | no (-1.000023847) |
| Ortholog in Animals | Alpaca_ ALG2 ( ortholog_one2one ) Dog_ ALG2 ( ortholog_one2one ) GuineaPig_ ALG2 ( ortholog_one2one ) Macaque_ ALG2 ( ortholog_one2one ) Mouse_ Alg2 ( ortholog_one2one ) Pig_ ALG2 ( ortholog_one2one ) Rat_ Alg2 ( ortholog_one2one ) Rabbit_ ALG2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ALG11, GLT1D1, PIGA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);0.042105(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ZN8 (X-ray 2.70A ) 2ZN9 (X-ray 2.40A ) 2ZND (X-ray 1.70A ) 2ZNE (X-ray 2.20A ) 2ZRS (X-ray 3.10A ) 2ZRT (X-ray 3.30A ) 3AAJ (X-ray 2.40A ) 3AAK (X-ray 2.70A ) 3WXA (X-ray 2.36A ) 5GQQ (X-ray 2.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:16957052, ECO:0000269|PubMed:27813252}; Peripheral membrane protein {ECO:0000269|PubMed:16957052}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:27716508}. Cytoplasm {ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27784779}. Nucleus {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:27784779}. Endosome {ECO:0000269|PubMed:19864416}. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus (PubMed:17045351). Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (PubMed:21122810). In response to calcium increase, relocates from cytoplasm to COPII vesicle coat (PubMed:27716508). Localizes to endoplasmic reticulum exit site (ERES) (PubMed:27813252). {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27813252}. |
| Mouse PG classification | LPG |
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