| Gene Information | |
|---|---|
| Gene Name | AFX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 505 |
| Protein Names | Forkhead box protein O4 (Fork head domain transcription factor AFX1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P98177 |
| Gene Card | FOXO4 |
| Uniprot ID | P98177 |
| Pfam | PF00250; PF16676 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.035650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1E17 (NMR - ) 3L2C (X-ray 1.87A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm. |
| Mouse PG classification | NA |
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