| Gene Information | |
|---|---|
| Gene Name | CABLES1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 633 |
| Protein Names | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000134508 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TDN4 |
| Gene Card | CABLES1 |
| Uniprot ID | Q8TDN4 |
| Pfam | PF00134 |
| In ASD | no |
| Allosteric Prediction | no (-0.610955197) |
| Ortholog in Animals | Alpaca_ CABLES1 ( ortholog_one2one ) Dog_ CABLES1 ( ortholog_one2one ) GuineaPig_ CABLES1 ( ortholog_one2one ) Macaque_ CABLES1 ( ortholog_one2one ) Mouse_ Cables1 ( ortholog_one2one ) Pig_ CABLES1 ( ortholog_one2one ) Rat_ Cables1 ( ortholog_one2one ) |
| Ohnologs | CABLES2 |
| Paralogs | CABLES2 |
| Tissue | NA |
| Tissue Specificity | Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. {ECO:0000269|PubMed:11585773, ECO:0000269|PubMed:14729625}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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