Gene Information
Gene NameALDH9A1
OrganismHomo sapiens (Human)
Gene Length494
Protein Names4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed]
Target Name4-trimethylaminobutyraldehyde dehydrogenase
Target TypeNA
Gene Age>4290 ( ENSG00000143149 )
Evolutionary StageEuk+Bac
AlphaFoldDBP49189
Gene CardALDH9A1
Uniprot IDP49189
PfamPF00171
In ASDno
Allosteric Predictionyes (0.328555047)
Ortholog in AnimalsAlpaca_ ALDH9A1 ( ortholog_one2one )
GuineaPig_ ALDH9A1 ( ortholog_one2one )
Macaque_ ALDH9A1 ( ortholog_many2many )
Mouse_ Aldh9a1 ( ortholog_many2many )
Rat_ Aldh9a1 ( ortholog_many2many )
OhnologsNA
ParalogsALDH7A1, ALDH1B1, ALDH3A2, ALDH1A1, ALDH3B1, ALDH3B2, ALDH3A1, ALDH2, ALDH1A2, ALDH6A1, ALDH5A1, ALDH1L1, ALDH1A3, ALDH1L2, ALDH8A1, ALDH4A1, ALDH16A1
TissueNA
Tissue SpecificityDetected in brain (at protein level) (PubMed:8645224). High expression in adult liver, skeletal muscle, and kidney. Low levels in heart, pancreas, lung and brain (PubMed:8786138). Expressed in all regions of the brain. Expression levels are variable in the different brain areas, with the highest levels in the spinal cord and the lowest in the occipital pole. {ECO:0000269|PubMed:8645224, ECO:0000269|PubMed:8786138}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6QAK  (X-ray  2.50A  )  6QAO  (X-ray  2.89A  )  6QAP  (X-ray  2.30A  )  6VR6  (X-ray  2.50A  )  6VWF  (X-ray  2.64A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JLJ3}.
Mouse PG classificationNA
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