| Gene Information | |
|---|---|
| Gene Name | ALDH7A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 539 |
| Protein Names | Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) |
| Target Name | alpha-aminoadipic semialdehyde dehydrogenase |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000164904 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P49419 |
| Gene Card | ALDH7A1 |
| Uniprot ID | P49419 |
| Pfam | PF00171 |
| In ASD | no |
| Allosteric Prediction | yes (1.072910219) |
| Ortholog in Animals | Alpaca_ ALDH7A1 ( ortholog_one2one ) Dog_ ALDH7A1 ( ortholog_one2one ) GuineaPig_ ALDH7A1 ( ortholog_one2one ) Macaque_ ALDH7A1 ( ortholog_one2one ) Mouse_ Aldh7a1 ( ortholog_one2one ) Pig_ ALDH7A1 ( ortholog_one2one ) Rat_ Aldh7a1 ( ortholog_one2one ) Rabbit_ ALDH7A1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ALDH1B1, ALDH3A2, ALDH1A1, ALDH3B1, ALDH3B2, ALDH3A1, ALDH2, ALDH9A1, ALDH1A2, ALDH6A1, ALDH5A1, ALDH1L1, ALDH1A3, ALDH1L2, ALDH8A1, ALDH4A1, ALDH16A1 |
| Tissue | NA |
| Tissue Specificity | Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue. {ECO:0000269|PubMed:8088832, ECO:0000269|PubMed:9417906}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2J6L (X-ray 1.30A ) 4X0T (X-ray 2.40A ) 4X0U (X-ray 1.95A ) 4ZUK (X-ray 2.00A ) 4ZUL (X-ray 1.76A ) 4ZVW (X-ray 2.40A ) 4ZVX (X-ray 1.90A ) 4ZVY (X-ray 1.90A ) 6O4B (X-ray 1.85A ) 6O4C (X-ray 1.70A ) 6O4D (X-ray 1.88A ) 6O4E (X-ray 1.75A ) 6O4F (X-ray 1.90A ) 6O4G (X-ray 2.05A ) 6O4H (X-ray 2.05A ) 6O4I (X-ray 1.75A ) 6O4K (X-ray 2.06A ) 6O4L (X-ray 1.85A ) 6U2X (X-ray 2.15A ) 6V0Z (X-ray 2.02A ) |
| DBSNP | rs121912709 rs121912711 rs754449549 rs2306618 rs121912707 rs12514417 |
| Subcellular location [CC] | [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:20207735}. Nucleus {ECO:0000269|PubMed:20207735}.; [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:20207735}. |
| Mouse PG classification | NA |
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