| Gene Information | |
|---|---|
| Gene Name | ALDH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 517 |
| Protein Names | Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) |
| Target Name | mitochondrial aldehyde dehydrogenase |
| Target Type | Clinical trial target |
| Gene Age | 886 ( ENSG00000111275 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P05091 |
| Gene Card | ALDH2 |
| Uniprot ID | P05091 |
| Pfam | PF00171 |
| In ASD | yes |
| Allosteric Prediction | yes (1.075094613) |
| Ortholog in Animals | Alpaca_ ALDH2 ( ortholog_one2one ) GuineaPig_ ALDH2 ( ortholog_one2one ) Mouse_ Aldh2 ( ortholog_one2one ) Pig_ ALDH2 ( ortholog_one2one ) Rat_ Acad10 ( ortholog_one2one ) Rabbit_ ALDH2 ( ortholog_one2one ) |
| Ohnologs | ALDH1A2 |
| Paralogs | ALDH7A1, ALDH1B1, ALDH3A2, ALDH1A1, ALDH3B1, ALDH3B2, ALDH3A1, ALDH9A1, ALDH1A2, ALDH6A1, ALDH5A1, ALDH1L1, ALDH1A3, ALDH1L2, ALDH8A1, ALDH4A1, ALDH16A1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1CW3 (X-ray 2.58A ) 1NZW (X-ray 2.65A ) 1NZX (X-ray 2.45A ) 1NZZ (X-ray 2.45A ) 1O00 (X-ray 2.60A ) 1O01 (X-ray 2.15A ) 1O02 (X-ray 1.90A ) 1O04 (X-ray 1.42A ) 1O05 (X-ray 2.25A ) 1ZUM (X-ray 2.10A ) 2ONM (X-ray 2.50A ) 2ONN (X-ray 2.75A ) 2ONO (X-ray 2.15A ) 2ONP (X-ray 2.00A ) 2VLE (X-ray 2.40A ) 3INJ (X-ray 1.69A ) 3INL (X-ray 1.86A ) 3N80 (X-ray 1.50A ) 3N81 (X-ray 1.70A ) 3N82 (X-ray 2.25A ) 3N83 (X-ray 1.90A ) 3SZ9 (X-ray 2.10A ) 4FQF (X-ray 2.28A ) 4FR8 (X-ray 2.20A ) 4KWF (X-ray 2.31A ) 4KWG (X-ray 2.10A ) 5L13 (X-ray 2.40A ) |
| DBSNP | rs1062136 rs769724893 rs671 |
| Subcellular location [CC] | Mitochondrion matrix. |
| Mouse PG classification | NA |
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