| Gene Information | |
|---|---|
| Gene Name | PPP3R1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 170 |
| Protein Names | Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) |
| Target Name | calcineurin subunit b type 1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000221823 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P63098 |
| Gene Card | PPP3R1 |
| Uniprot ID | P63098 |
| Pfam | PF13499 |
| In ASD | no |
| Allosteric Prediction | no (-0.08821206) |
| Ortholog in Animals | Alpaca_ PPP3R1 ( ortholog_one2one ) Dog_ PPP3R1 ( ortholog_one2one ) GuineaPig_ PPP3R1 ( ortholog_one2one ) Macaque_ PPP3R1 ( ortholog_one2one ) Mouse_ Ppp3r1 ( ortholog_one2one ) Pig_ PPP3R1 ( ortholog_one2one ) Rabbit_ PPP3R1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CIB1, CIB4, CHP1, CIB3, TESC, CIB2, CHP2, PPP3R2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001860(Rat);0.027273(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1AUI (X-ray 2.10A ) 1M63 (X-ray 2.80A ) 1MF8 (X-ray 3.10A ) 2P6B (X-ray 2.30A ) 3LL8 (X-ray 2.00A ) 4F0Z (X-ray 1.70A ) 4OR9 (X-ray 2.23A ) 4ORA (X-ray 2.75A ) 4ORC (X-ray 2.70A ) 5SVE (X-ray 2.60A ) 6NUC (X-ray 1.90A ) 6NUF (X-ray 1.90A ) 6NUU (X-ray 2.30A ) 7U0T (X-ray 2.45A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q63810}. Cell membrane {ECO:0000250|UniProtKB:Q63810}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q63810}. Cell membrane {ECO:0000269|PubMed:25255805}; Lipid-anchor {ECO:0000269|PubMed:25255805}. Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy. {ECO:0000250|UniProtKB:Q63810}. |
| Mouse PG classification | NA |
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