| Gene Information | |
|---|---|
| Gene Name | ALDH1A3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 512 |
| Protein Names | Aldehyde dehydrogenase family 1 member A3 (EC 1.2.1.36) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3) (RalDH3) |
| Target Name | aldehyde dehydrogenase family 1 member a3 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000184254 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P47895 |
| Gene Card | ALDH1A3 |
| Uniprot ID | P47895 |
| Pfam | PF00171 |
| In ASD | no |
| Allosteric Prediction | yes (0.028088537) |
| Ortholog in Animals | Alpaca_ ALDH1A3 ( ortholog_one2one ) Dog_ ALDH1A3 ( ortholog_one2one ) Macaque_ ALDH1A3 ( ortholog_one2one ) Mouse_ Aldh1a3 ( ortholog_one2one ) Pig_ ALDH1A3 ( ortholog_one2one ) Rat_ Aldh1a3 ( ortholog_one2one ) |
| Ohnologs | ALDH1B1, ALDH1A1 |
| Paralogs | ALDH7A1, ALDH1B1, ALDH3A2, ALDH1A1, ALDH3B1, ALDH3B2, ALDH3A1, ALDH2, ALDH9A1, ALDH1A2, ALDH6A1, ALDH5A1, ALDH1L1, ALDH1L2, ALDH8A1, ALDH4A1, ALDH16A1 |
| Tissue | NA |
| Tissue Specificity | Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney. {ECO:0000269|PubMed:7698756}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5FHZ (X-ray 2.90A ) 6S6W (X-ray 3.25A ) 6TE5 (X-ray 3.25A ) 6TGW (X-ray 2.80A ) 6TRY (X-ray 2.90A ) 7A6Q (X-ray 2.95A ) 7QK7 (X-ray 2.29A ) 7QK8 (X-ray 1.89A ) 7QK9 (X-ray 1.78A ) |
| DBSNP | rs386834230 rs397514652 rs754619607 rs3803430 rs397514653 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q9JHW9}. |
| Mouse PG classification | HPG |
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