Gene Information
Gene NameALDH1A1
OrganismHomo sapiens (Human)
Gene Length501
Protein NamesAldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1)
Target Nameretinal dehydrogenase 1
Target TypeNA
Gene Age>4290 ( ENSG00000165092 )
Evolutionary StageEuk+Bac
AlphaFoldDBP00352
Gene CardALDH1A1
Uniprot IDP00352
PfamPF00171
In ASDno
Allosteric Predictionyes (0.361144764)
Ortholog in AnimalsAlpaca_ ALDH1A1 ( ortholog_one2one )
Dog_ ALDH1A1 ( ortholog_one2one )
Macaque_ ALDH1A1 ( ortholog_one2one )
Mouse_ Aldh1a7 ( ortholog_one2many )
Mouse_ Aldh1a1 ( ortholog_one2many )
Pig_ ALDH1A1 ( ortholog_one2one )
Rat_ Aldh1a7 ( ortholog_one2many )
Rat_ Aldh1a1 ( ortholog_one2many )
Rabbit_ ALDH1A1 ( ortholog_one2one )
OhnologsALDH1A2, ALDH1A3
ParalogsALDH7A1, ALDH1B1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH3A1, ALDH2, ALDH9A1, ALDH1A2, ALDH6A1, ALDH5A1, ALDH1L1, ALDH1A3, ALDH1L2, ALDH8A1, ALDH4A1, ALDH16A1
Tissuecerebellum
Tissue SpecificityExpressed by erythrocytes (at protein level). {ECO:0000269|PubMed:17175089}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4WB9  (X-ray  2.07A  )  4WJ9  (X-ray  1.74A  )  4WP7  (X-ray  1.80A  )  4WPN  (X-ray  1.95A  )  4X4L  (X-ray  1.85A  )  5AC2  (X-ray  1.85A  )  5L2M  (X-ray  1.70A  )  5L2N  (X-ray  1.70A  )  5L2O  (X-ray  2.05A  )  5TEI  (X-ray  2.10A  )  6DUM  (X-ray  2.00A  )  7JWS  (X-ray  1.60A  )  7JWT  (X-ray  1.80A  )  7JWU  (X-ray  1.90A  )  7JWV  (X-ray  1.60A  )  7JWW  (X-ray  1.60A  ) 
DBSNP rs1049981  rs11554423  rs8187929 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:12941160}. Cell projection, axon {ECO:0000250|UniProtKB:P24549}.
Mouse PG classificationNA
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