| Gene Information | |
|---|---|
| Gene Name | ALDH18A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 795 |
| Protein Names | Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] |
| Target Name | delta-1-pyrroline-5-carboxylate synthase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000059573 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P54886 |
| Gene Card | ALDH18A1 |
| Uniprot ID | P54886 |
| Pfam | PF00696; PF00171 |
| In ASD | yes |
| Allosteric Prediction | yes (0.047288749) |
| Ortholog in Animals | Alpaca_ ALDH18A1 ( ortholog_one2one ) Dog_ ALDH18A1 ( ortholog_one2one ) GuineaPig_ ALDH18A1 ( ortholog_one2one ) Macaque_ ALDH18A1 ( ortholog_one2one ) Mouse_ Aldh18a1 ( ortholog_one2one ) Pig_ ALDH18A1 ( ortholog_one2one ) Rat_ Aldh18a1 ( ortholog_one2one ) Rabbit_ ALDH18A1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2H5G (X-ray 2.25A ) |
| DBSNP | rs121434582 rs863224945 rs768323248 rs863225045 rs863225045 rs863225044 rs864321669 rs864321670 rs2275272 rs3765571 rs869320690 rs766264810 rs752669339 rs774047299 rs121434583 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000269|PubMed:26297558, ECO:0000269|PubMed:26320891}. |
| Mouse PG classification | NA |
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