| Gene Information | |
|---|---|
| Gene Name | ALC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 897 |
| Protein Names | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q86WJ1 |
| Gene Card | CHD1L |
| Uniprot ID | Q86WJ1 |
| Pfam | PF00271; PF00176 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Frequently overexpressed in hepatomacellular carcinomas. {ECO:0000269|PubMed:18023026}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.045455(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6ZHX (EM 2.50A ) 6ZHY (EM 3.00A ) 7ENN (EM 2.80A ) 7EPU (X-ray 3.50A ) 7OTQ (EM 4.80A ) |
| DBSNP | rs11588753 rs17356233 rs13374920 rs2275249 rs1553974573 rs1180954265 rs139712616 rs4950394 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19661379}. Chromosome {ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:29220652, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34874266}. Note=Localizes at sites of DNA damage; recruited by histones H2B and H3 poly-ADP-ribosylated on 'Ser-6' and 'Ser-10', respectively (H2BS6ADPr and H3S10ADPr) by PARP1 or PARP2. {ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34874266}. |
| Mouse PG classification | NA |
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