| Gene Information | |
|---|---|
| Gene Name | ALAS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 640 |
| Protein Names | 5-aminolevulinate synthase, non-specific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1) |
| Target Name | 5-aminolevulinate synthase, nonspecific, mitochondrial |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000023330 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P13196 |
| Gene Card | ALAS1 |
| Uniprot ID | P13196 |
| Pfam | PF00155; PF09029 |
| In ASD | no |
| Allosteric Prediction | yes (0.40007988) |
| Ortholog in Animals | Alpaca_ ALAS1 ( ortholog_one2one ) Dog_ ALAS1 ( ortholog_one2one ) GuineaPig_ ALAS1 ( ortholog_one2one ) Macaque_ ALAS1 ( ortholog_one2one ) Mouse_ Alas1 ( ortholog_one2one ) Pig_ ALAS1 ( ortholog_one2one ) Rat_ Alas1 ( ortholog_one2one ) Rabbit_ ALAS1 ( ortholog_one2one ) |
| Ohnologs | ALAS2 |
| Paralogs | GCAT, ALAS2, SPTLC3, SPTLC2, SPTLC1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000250|UniProtKB:P22557}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22557}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000250|UniProtKB:P22557}. |
| Mouse PG classification | NA |
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