| Gene Information | |
|---|---|
| Gene Name | AKT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 481 |
| Protein Names | RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta) |
| Target Name | rac-beta serine/threonine-protein kinase |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000105221 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P31751 |
| Gene Card | AKT2 |
| Uniprot ID | P31751 |
| Pfam | PF00169; PF00069; PF00433 |
| In ASD | yes |
| Allosteric Prediction | yes (1.46619171) |
| Ortholog in Animals | Alpaca_ AKT2 ( ortholog_one2one ) Dog_ AKT2 ( ortholog_one2one ) GuineaPig_ AKT2 ( ortholog_one2one ) Macaque_ AKT2 ( ortholog_one2one ) Mouse_ Akt2 ( ortholog_one2one ) Pig_ AKT2 ( ortholog_one2one ) Rat_ Akt2 ( ortholog_one2one ) Rabbit_ AKT2 ( ortholog_one2one ) |
| Ohnologs | AKT3, AKT1 |
| Paralogs | AKT3, PDPK1, AKT1, PRKCD, PRKCQ |
| Tissue | NA |
| Tissue Specificity | Expressed in all cell types so far analyzed. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001942(Rat);0.037037(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1GZK (X-ray 2.30A ) 1GZN (X-ray 2.50A ) 1GZO (X-ray 2.75A ) 1MRV (X-ray 2.80A ) 1MRY (X-ray 2.80A ) 1O6K (X-ray 1.70A ) 1O6L (X-ray 1.60A ) 1P6S (NMR - ) 2JDO (X-ray 1.80A ) 2JDR (X-ray 2.30A ) 2UW9 (X-ray 2.10A ) 2X39 (X-ray 1.93A ) 2XH5 (X-ray 2.72A ) 3D0E (X-ray 2.00A ) 3E87 (X-ray 2.30A ) 3E88 (X-ray 2.50A ) 3E8D (X-ray 2.70A ) |
| DBSNP | rs387906659 rs55859611 rs35817154 rs121434593 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Early endosome {ECO:0000250|UniProtKB:Q60823}. Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes (By similarity). {ECO:0000250|UniProtKB:Q60823}. |
| Mouse PG classification | NA |
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