| Gene Information | |
|---|---|
| Gene Name | AKT1S1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 256 |
| Protein Names | Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000204673 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q96B36 |
| Gene Card | AKT1S1 |
| Uniprot ID | Q96B36 |
| Pfam | PF15798 |
| In ASD | no |
| Allosteric Prediction | yes (0.086308419) |
| Ortholog in Animals | Alpaca_ AKT1S1 ( ortholog_one2one ) Dog_ AKT1S1 ( ortholog_one2one ) GuineaPig_ AKT1S1 ( ortholog_one2one ) Macaque_ AKT1S1 ( ortholog_one2one ) Mouse_ Akt1s1 ( ortholog_one2one ) Pig_ AKT1S1 ( ortholog_one2one ) Rat_ Akt1s1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A-549 and HeLa) than in normal cell lines (e.g. HEK293). {ECO:0000269|PubMed:12524439, ECO:0000269|PubMed:16174443}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5WBL (X-ray 3.35A ) 5WBU (X-ray 3.42A ) 5WBY (X-ray 3.10A ) 6SB0 (EM 5.50A ) |
| DBSNP | rs17850191 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250}. Note=Found in the cytosolic fraction of the brain. {ECO:0000250}. |
| Mouse PG classification | NA |
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