| Gene Information | |
|---|---|
| Gene Name | EIF2AK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 630 |
| Protein Names | Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) |
| Target Name | eukaryotic translation initiation factor 2-alpha kinase 1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000086232 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BQI3 |
| Gene Card | EIF2AK1 |
| Uniprot ID | Q9BQI3 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.301496815) |
| Ortholog in Animals | Alpaca_ EIF2AK1 ( ortholog_one2many ) Dog_ EIF2AK1 ( ortholog_one2one ) GuineaPig_ EIF2AK1 ( ortholog_one2one ) Macaque_ EIF2AK1 ( ortholog_one2one ) Mouse_ Eif2ak1 ( ortholog_one2one ) Pig_ EIF2AK1 ( ortholog_one2one ) Rat_ Eif2ak1 ( ortholog_one2one ) Rabbit_ EIF2AK1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | STK35, PKMYT1, EIF2AK3, EIF2AK4, WEE2, EIF2AK2, WEE1, PDIK1L |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34889754 rs34851195 rs55744865 rs55963745 rs55971369 rs1216460058 rs55982710 rs34909691 rs1583476115 rs2640 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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