| Gene Information | |
|---|---|
| Gene Name | AKR1D1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 326 |
| Protein Names | Aldo-keto reductase family 1 member D1 (EC 1.3.1.3) (3-oxo-5-beta-steroid 4-dehydrogenase) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase) |
| Target Name | 3-oxo-5-beta-steroid 4-dehydrogenase |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000122787 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P51857 |
| Gene Card | AKR1D1 |
| Uniprot ID | P51857 |
| Pfam | PF00248 |
| In ASD | no |
| Allosteric Prediction | yes (0.168044856) |
| Ortholog in Animals | Alpaca_ AKR1D1 ( ortholog_one2one ) GuineaPig_ AKR1D1 ( ortholog_one2one ) Macaque_ AKR1D1 ( ortholog_one2one ) Mouse_ Akr1d1 ( ortholog_one2one ) Pig_ AKR1D1 ( ortholog_one2one ) Rat_ Akr1d1 ( ortholog_one2one ) |
| Ohnologs | AKR1C2, AKR1C1, AKR1C3, AKR1C4 |
| Paralogs | AKR1C8, AKR7A3, KCNAB1, KCNAB3, AKR7A2, AKR1C3, AKR1C1, AKR1B1, AKR1E2, AKR1C4, AKR1A1, AKR1C2, AKR1B15, AKR1B10, KCNAB2, AKR7L |
| Tissue | liver |
| Tissue Specificity | Highly expressed in liver. Expressed in testis and weakly in colon. {ECO:0000269|PubMed:11342103}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3BUR (X-ray 1.62A ) 3BUV (X-ray 1.35A ) 3BV7 (X-ray 1.79A ) 3CAQ (X-ray 2.20A ) 3CAS (X-ray 2.00A ) 3CAV (X-ray 1.90A ) 3CMF (X-ray 1.90A ) 3COT (X-ray 2.03A ) 3DOP (X-ray 2.00A ) 3G1R (X-ray 1.70A ) 3UZW (X-ray 1.89A ) 3UZX (X-ray 1.64A ) 3UZY (X-ray 1.83A ) 3UZZ (X-ray 1.82A ) |
| DBSNP | rs121918343 rs267606649 rs121918342 rs1228918719 rs267606650 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:7508385}. |
| Mouse PG classification | NA |
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