| Gene Information | |
|---|---|
| Gene Name | AKR1C4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 323 |
| Protein Names | Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha-hydroxysteroid dehydrogenase type I) (3-alpha-HSD1) (EC 1.1.1.357) (3alpha-hydroxysteroid 3-dehydrogenase) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA) |
| Target Name | aldo-keto reductase family 1 member c4 |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000198610 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P17516 |
| Gene Card | AKR1C4 |
| Uniprot ID | P17516 |
| Pfam | PF00248 |
| In ASD | no |
| Allosteric Prediction | yes (0.30969205) |
| Ortholog in Animals | Alpaca_ AKR1C4 ( ortholog_one2one ) |
| Ohnologs | AKR1D1 |
| Paralogs | AKR1C8, AKR7A3, KCNAB1, KCNAB3, AKR7A2, AKR1C3, AKR1C1, AKR1B1, AKR1E2, AKR1A1, AKR1C2, AKR1B15, AKR1B10, KCNAB2, AKR7L, AKR1D1 |
| Tissue | liver |
| Tissue Specificity | Liver specific. {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11158055, ECO:0000269|PubMed:7650035}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2FVL (X-ray 2.40A ) |
| DBSNP | rs11253043 rs3829125 rs17851824 rs4880718 rs17134592 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04828}. |
| Mouse PG classification | NA |
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