Gene Information
Gene NameAKR1C2
OrganismHomo sapiens (Human)
Gene Length323
Protein NamesAldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357)
Target Namealdo-keto reductase family 1 member c2
Target TypeNA
Gene Age25 ( ENSG00000151632 )
Evolutionary StageCellular_organisms
AlphaFoldDBP52895
Gene CardAKR1C2
Uniprot IDP52895
PfamPF00248
In ASDyes
Allosteric Predictionyes (1.000377442)
Ortholog in AnimalsAlpaca_ AKR1C2 ( ortholog_one2one )
OhnologsAKR1D1
ParalogsAKR1C8, AKR7A3, KCNAB1, KCNAB3, AKR7A2, AKR1C3, AKR1C1, AKR1B1, AKR1E2, AKR1C4, AKR1A1, AKR1B15, AKR1B10, KCNAB2, AKR7L, AKR1D1
TissueNA
Tissue SpecificityExpressed in fetal testes. Expressed in fetal and adult adrenal glands. {ECO:0000269|PubMed:21802064}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1IHI  (X-ray  3.00A  )  1J96  (X-ray  1.25A  )  1XJB  (X-ray  1.90A  )  2HDJ  (X-ray  2.00A  )  2IPJ  (X-ray  1.80A  )  4JQ1  (X-ray  1.60A  )  4JQ2  (X-ray  1.75A  )  4JQ3  (X-ray  1.75A  )  4JQ4  (X-ray  1.52A  )  4JQA  (X-ray  1.45A  )  4JTQ  (X-ray  1.60A  )  4JTR  (X-ray  1.30A  )  4L1W  (X-ray  2.20A  )  4L1X  (X-ray  2.00A  )  4XO6  (X-ray  1.20A  )  4XO7  (X-ray  1.75A  ) 
DBSNP rs2854482  rs387906750  rs797044460  rs11474  rs13222  rs387906751 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000305|PubMed:8486699}.
Mouse PG classificationNA
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