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Gene Information
Gene Name
AKR1B1
Organism
Homo sapiens (Human)
Gene Length
316
Protein Names
Aldo-keto reductase family 1 member B1 (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) (EC 1.1.1.21)
Target Name
aldose reductase
Target Type
NA
Gene Age
>4290 ( ENSG00000085662 )
Evolutionary Stage
Euk+Bac
AlphaFoldDB
P15121
Gene Card
AKR1B1
Uniprot ID
P15121
Pfam
PF00248
In ASD
no
Allosteric Prediction
yes (1.047672121)
Ortholog in Animals
Alpaca_ AKR1B1 ( ortholog_one2one )
Dog_ AKR1B1 ( ortholog_one2many )
GuineaPig_ AKR1B1 ( ortholog_one2one )
Macaque_ AKR1B1 ( ortholog_one2one )
Mouse_ Akr1b3 ( ortholog_one2one )
Pig_ AKR1B1 ( ortholog_one2one )
Rat_ Akr1b1-ps2 ( ortholog_one2many )
Rat_ AC127963.2 ( ortholog_one2many )
Rat_ Akr1b1 ( ortholog_one2many )
Rat_ Akr1b1-ps1 ( ortholog_one2many )
Rabbit_ AKR1B1 ( ortholog_one2one )
Ohnologs
AKR1E2
Paralogs
AKR1E2, AKR1C8, AKR7A3, KCNAB1, KCNAB3, AKR7A2, AKR1C3, AKR1C1, AKR1C4, AKR1A1, AKR1C2, AKR1B15, AKR1B10, KCNAB2, AKR7L, AKR1D1
Tissue
NA
Tissue Specificity
Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. {ECO:0000269|PubMed:8435445}.
Pharmacological Animal Models
NA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1ABN
(X-ray
2.40A
)
1ADS
(X-ray
1.65A
)
1AZ1
(X-ray
1.80A
)
1AZ2
(X-ray
2.90A
)
1EF3
(X-ray
2.80A
)
1EL3
(X-ray
1.70A
)
1IEI
(X-ray
2.50A
)
1MAR
(X-ray
1.80A
)
1PWL
(X-ray
1.10A
)
1PWM
(X-ray
0.92A
)
1T40
(X-ray
1.80A
)
1T41
(X-ray
1.05A
)
1US0
(X-ray
0.66A
)
1X96
(X-ray
1.40A
)
1X97
(X-ray
1.40A
)
1X98
(X-ray
1.30A
)
1XGD
(X-ray
2.10A
)
1Z3N
(X-ray
1.04A
)
1Z89
(X-ray
1.43A
)
1Z8A
(X-ray
0.95A
)
2ACQ
(X-ray
1.76A
)
2ACR
(X-ray
1.76A
)
2ACS
(X-ray
1.76A
)
2ACU
(X-ray
1.76A
)
2AGT
(X-ray
1.00A
)
2DUX
(X-ray
1.60A
)
2DUZ
(X-ray
1.60A
)
2DV0
(X-ray
1.62A
)
2F2K
(X-ray
1.94A
)
2FZ8
(X-ray
1.48A
)
2FZ9
(X-ray
1.60A
)
2FZB
(X-ray
1.50A
)
2FZD
(X-ray
1.08A
)
2HV5
(X-ray
1.59A
)
2HVN
(X-ray
1.58A
)
2HVO
(X-ray
1.65A
)
2I16
(X-ray
0.81A
)
2I17
(X-ray
0.81A
)
2IKG
(X-ray
1.43A
)
2IKH
(X-ray
1.55A
)
2IKI
(X-ray
1.47A
)
2IKJ
(X-ray
1.55A
)
2INE
(X-ray
1.90A
)
2INZ
(X-ray
1.95A
)
2IPW
(X-ray
2.00A
)
2IQ0
(X-ray
1.95A
)
2IQD
(X-ray
2.00A
)
2IS7
(X-ray
1.70A
)
2ISF
(X-ray
2.00A
)
2J8T
(X-ray
0.82A
)
2NVC
(X-ray
1.65A
)
2NVD
(X-ray
1.55A
)
2PD5
(X-ray
1.60A
)
2PD9
(X-ray
1.55A
)
2PDB
(X-ray
1.60A
)
2PDC
(X-ray
1.65A
)
2PDF
(X-ray
1.56A
)
2PDG
(X-ray
1.42A
)
2PDH
(X-ray
1.45A
)
2PDI
(X-ray
1.55A
)
2PDJ
(X-ray
1.57A
)
2PDK
(X-ray
1.55A
)
2PDL
(X-ray
1.47A
)
2PDM
(X-ray
1.75A
)
2PDN
(X-ray
1.70A
)
2PDP
(X-ray
1.65A
)
2PDQ
(X-ray
1.73A
)
2PDU
(X-ray
1.55A
)
2PDW
(X-ray
1.55A
)
2PDX
(X-ray
1.65A
)
2PDY
(X-ray
1.65A
)
2PEV
(X-ray
0.90A
)
2PF8
(X-ray
0.85A
)
2PFH
(X-ray
0.85A
)
2PZN
(X-ray
1.00A
)
2QXW
(X-ray
0.80A
)
2R24
(X-ray
1.75A
)
3BCJ
(X-ray
0.78A
)
3DN5
(X-ray
1.45A
)
3G5E
(X-ray
1.80A
)
3GHR
(X-ray
1.00A
)
3GHS
(X-ray
1.00A
)
3GHT
(X-ray
1.10A
)
3GHU
(X-ray
1.20A
)
3LBO
(X-ray
1.10A
)
3LD5
(X-ray
1.27A
)
3LEN
(X-ray
1.21A
)
3LEP
(X-ray
0.99A
)
3LQG
(X-ray
1.35A
)
3LQL
(X-ray
1.13A
)
3LZ3
(X-ray
1.03A
)
3LZ5
(X-ray
0.95A
)
3M0I
(X-ray
1.07A
)
3M4H
(X-ray
0.94A
)
3M64
(X-ray
1.30A
)
3MB9
(X-ray
1.65A
)
3MC5
(X-ray
1.14A
)
3ONB
(X-ray
1.45A
)
3ONC
(X-ray
1.06A
)
3P2V
(X-ray
1.69A
)
3Q65
(X-ray
2.09A
)
3Q67
(X-ray
1.55A
)
3RX2
(X-ray
1.90A
)
3RX3
(X-ray
1.90A
)
3RX4
(X-ray
2.00A
)
3S3G
(X-ray
1.80A
)
3T42
(X-ray
1.28A
)
3U2C
(X-ray
1.00A
)
3V35
(X-ray
1.90A
)
3V36
(X-ray
2.00A
)
4GCA
(X-ray
0.90A
)
4GQ0
(X-ray
2.10A
)
4IGS
(X-ray
0.85A
)
4JIR
(X-ray
2.00A
)
4LAU
(X-ray
0.84A
)
4LAZ
(X-ray
0.85A
)
4LB3
(X-ray
0.80A
)
4LB4
(X-ray
0.80A
)
4LBR
(X-ray
0.80A
)
4LBS
(X-ray
0.76A
)
4NKC
(X-ray
1.12A
)
4PR4
(X-ray
1.06A
)
4PRR
(X-ray
1.01A
)
4PRT
(X-ray
0.96A
)
4PUU
(X-ray
1.14A
)
4PUW
(X-ray
1.12A
)
4Q7B
(X-ray
1.19A
)
4QBX
(X-ray
0.98A
)
4QR6
(X-ray
1.05A
)
4QX4
(X-ray
1.26A
)
4QXI
(X-ray
0.87A
)
4RPQ
(X-ray
1.20A
)
4XZH
(X-ray
1.00A
)
4XZI
(X-ray
2.45A
)
4YS1
(X-ray
1.07A
)
4YU1
(X-ray
1.02A
)
5HA7
(X-ray
1.65A
)
5OU0
(X-ray
0.94A
)
5OUJ
(X-ray
0.96A
)
5OUK
(X-ray
0.96A
)
6F7R
(X-ray
0.92A
)
6F81
(X-ray
0.97A
)
6F82
(X-ray
1.03A
)
6F84
(X-ray
1.09A
)
6F8O
(X-ray
1.17A
)
6SYW
(X-ray
0.93A
)
6T27
(X-ray
1.11A
)
6T3P
(X-ray
0.97A
)
6T5G
(X-ray
1.28A
)
6T7Q
(X-ray
1.01A
)
6TD8
(X-ray
0.97A
)
6TUC
(X-ray
1.06A
)
6TUF
(X-ray
1.15A
)
6TXP
(X-ray
0.95A
)
6XUM
(X-ray
0.97A
)
6Y03
(X-ray
1.69A
)
6Y1P
(X-ray
0.94A
)
DBSNP
rs5054
rs5056
rs5057
rs2229542
rs5061
rs5062
Subcellular location [CC]
Cytoplasm.
Mouse PG classification
NA
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