| Gene Information | |
|---|---|
| Gene Name | AKNA |
| Organism | Homo sapiens (Human) |
| Gene Length | 1439 |
| Protein Names | Microtubule organization protein AKNA (AT-hook-containing transcription factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000106948 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q7Z591 |
| Gene Card | AKNA |
| Uniprot ID | Q7Z591 |
| Pfam | PF12443 |
| In ASD | no |
| Allosteric Prediction | no (-1.19296135) |
| Ortholog in Animals | Alpaca_ AKNA ( ortholog_one2one ) Dog_ AKNA ( ortholog_one2one ) GuineaPig_ AKNA ( ortholog_one2one ) Macaque_ AKNA ( ortholog_one2one ) Mouse_ Akna ( ortholog_one2one ) Pig_ AKNA ( ortholog_one2one ) Rat_ Akna ( ortholog_one2one ) Rabbit_ AKNA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AKNAD1 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a(+)CD14(-) but not CD1a(-)CD14(+) dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow. {ECO:0000269|PubMed:11268217}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs3748176 rs1265891 rs3748178 rs2250242 rs2787344 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q80VW7}. Nucleus {ECO:0000269|PubMed:11268217}. Note=Localizes to the distal part of the subdistal appendages of the mother centriole in interphase. Also found at the proximal ends of centrioles and along microtubules. The centrosomal localization is dependent on centrioles. Dissociates from centrosomes during M-phase without proteolytic degradation and reassembles at the centrosomes during late telophase and early G1 phase. Dissociation and reassembly is regulated by phosphorylation. {ECO:0000250|UniProtKB:Q80VW7}. |
| Mouse PG classification | NA |
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