| Gene Information | |
|---|---|
| Gene Name | AKAP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 692 |
| Protein Names | A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000105127 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O43823 |
| Gene Card | AKAP8 |
| Uniprot ID | O43823 |
| Pfam | PF04988 |
| In ASD | no |
| Allosteric Prediction | no (-0.227322864) |
| Ortholog in Animals | Alpaca_ AKAP8 ( ortholog_one2one ) Dog_ AKAP8 ( ortholog_one2one ) GuineaPig_ AKAP8 ( ortholog_one2one ) Macaque_ AKAP8 ( ortholog_one2one ) Mouse_ Akap8 ( ortholog_one2one ) Pig_ AKAP8 ( ortholog_one2one ) Rat_ Akap8 ( ortholog_one2one ) Rabbit_ AKAP8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AKAP8L, ZNF326 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Expressed in mature dendritic cells. {ECO:0000269|PubMed:19277197}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19277197, ECO:0000269|PubMed:26683827}. Nucleus matrix {ECO:0000269|PubMed:10601332}. Nucleus, nucleolus {ECO:0000269|PubMed:26683827}. Cytoplasm {ECO:0000250|UniProtKB:Q9DBR0}. Note=Associated with the nuclear matrix in interphase and redistributes mostly to chromatin at mitosis. However, mitotic chromatin localization has been questioned. Upon nuclear reassembly at the end of mitosis, is sequestered into the daughter nuclei where it re-acquires an interphase distribution. Exhibits partial localization to the nucleolus in interphase, where it colocalizes with UBTF/UBF, suggesting localization to the fibrillary center and/or to the dense fibrillary component. Colocalizes with GJA1 at the nuclear membrane specifically during cell cycle G1/S phase. {ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274}. |
| Mouse PG classification | NA |
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