| Gene Information | |
|---|---|
| Gene Name | AKAP5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 427 |
| Protein Names | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000179841 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P24588 |
| Gene Card | AKAP5 |
| Uniprot ID | P24588 |
| Pfam | PF03832 |
| In ASD | no |
| Allosteric Prediction | yes (0.965787823) |
| Ortholog in Animals | Alpaca_ AKAP5 ( ortholog_one2one ) Dog_ AKAP5 ( ortholog_one2one ) Macaque_ AKAP5 ( ortholog_one2one ) Mouse_ Akap5 ( ortholog_one2one ) Pig_ AKAP5 ( ortholog_one2one ) Rat_ Akap5 ( ortholog_one2one ) Rabbit_ AKAP5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.058824(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2H9R (NMR - ) 3LL8 (X-ray 2.00A ) 5NIN (X-ray 1.70A ) |
| DBSNP | rs2230491 rs1256149 rs34433837 |
| Subcellular location [CC] | Postsynaptic recycling endosome membrane {ECO:0000269|PubMed:21771783, ECO:0000269|PubMed:25589740}; Lipid-anchor {ECO:0000269|PubMed:21771783}. Note=Associates with lipid rafts. {ECO:0000269|PubMed:21771783}. |
| Mouse PG classification | NA |
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