| Gene Information | |
|---|---|
| Gene Name | AKAP13 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2813 |
| Protein Names | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000170776 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | NA |
| Gene Card | AKAP13 |
| Uniprot ID | Q12802 |
| Pfam | PF17838; PF00621; PF10522 |
| In ASD | no |
| Allosteric Prediction | yes (0.234738407) |
| Ortholog in Animals | Alpaca_ AKAP13 ( ortholog_one2one ) Dog_ AKAP13 ( ortholog_one2one ) Macaque_ AKAP13 ( ortholog_one2one ) Mouse_ Akap13 ( ortholog_one2one ) Rat_ Akap13 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in mammary gland (PubMed:9627117). Detected in heart (at protein level) (PubMed:11546812). Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle. {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DRN (NMR - ) 2LG1 (NMR - ) 4D0N (X-ray 2.10A ) 4D0O (X-ray 2.75A ) 6BCA (X-ray 2.00A ) |
| DBSNP | rs2061821 rs2061822 rs34434221 rs2061824 rs745191 rs7177107 rs4075256 rs4075254 rs4843074 rs4843075 rs7162168 rs35079107 rs2241268 rs2614668 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:9891067}. Cytoplasm {ECO:0000269|PubMed:9627117}. Cytoplasm, cell cortex {ECO:0000269|PubMed:11546812}. Nucleus {ECO:0000269|PubMed:9627117}. Membrane {ECO:0000269|PubMed:11696353, ECO:0000269|PubMed:9891067}; Peripheral membrane protein {ECO:0000269|PubMed:11696353, ECO:0000305|PubMed:9891067}. Note=Colocalizes with the actin cytoskeleton at the cell cortex. {ECO:0000269|PubMed:11546812}. |
| Mouse PG classification | NA |
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