| Gene Information | |
|---|---|
| Gene Name | NRP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 810 |
| Protein Names | Protein kinase C-binding protein NELL1 (NEL-like protein 1) (Nel-related protein 1) |
| Target Name | neuropilin-1 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000099250 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q92832 |
| Gene Card | NELL1 |
| Uniprot ID | Q92832 |
| Pfam | PF12947; PF07645; PF02210; PF00093 |
| In ASD | no |
| Allosteric Prediction | yes (0.142610412) |
| Ortholog in Animals | Alpaca_ NRP1 ( ortholog_one2one ) Dog_ NRP1 ( ortholog_one2one ) GuineaPig_ NRP1 ( ortholog_one2one ) Macaque_ NRP1 ( ortholog_one2one ) Mouse_ Nrp1 ( ortholog_one2one ) Pig_ NRP1 ( ortholog_one2one ) Rat_ Nrp1 ( ortholog_one2one ) Rabbit_ NRP1 ( ortholog_one2one ) |
| Ohnologs | NRP2 |
| Paralogs | CNTNAP3B, CNTNAP3, CNTNAP3C, CNTNAP4, PDGFD, ASTL, CNTNAP5, HEPH, MEP1A, NRXN2, CNTNAP2, MFRP, CUZD1, NETO2, TLL2, F5, PCOLCE, CP, NRXN3, EDIL3, CNTNAP1, CUBN, MEP1B, NETO1, MFGE8, PCOLCE2, NRP2, HEPHL1, F8, TLL1, NRXN1, DCBLD2, PDGFC, CDCP2, BMP1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6POL (X-ray 1.80A ) |
| DBSNP | rs8176785 rs35809043 rs11820003 rs8176786 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21723284}. Nucleus envelope {ECO:0000269|PubMed:21723284}. Secreted {ECO:0000250}. Note=Colocalizes with ATRAID on the nuclear envelope and the perinuclear region. |
| Mouse PG classification | NA |
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