| Gene Information | |
|---|---|
| Gene Name | AK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 223 |
| Protein Names | Adenylate kinase 4, mitochondrial (AK 4) (EC 2.7.4.10) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000147853 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P27144 |
| Gene Card | AK4 |
| Uniprot ID | P27144 |
| Pfam | PF05191 |
| In ASD | no |
| Allosteric Prediction | no (-0.088256781) |
| Ortholog in Animals | Alpaca_ AK3 ( ortholog_one2one ) GuineaPig_ AK3 ( ortholog_one2one ) Macaque_ AK3 ( ortholog_one2one ) Mouse_ Ak3 ( ortholog_one2one ) Pig_ AK3 ( ortholog_one2one ) Rat_ Ak3 ( ortholog_one2one ) |
| Ohnologs | AK4 |
| Paralogs | CMPK1, AK5, AK1, AK7, AK9, AK2, AK8, AK4, AK4P3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain. {ECO:0000269|PubMed:11485571}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2AR7 (X-ray 2.15A ) 2BBW (X-ray 2.05A ) 3NDP (X-ray 2.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03170, ECO:0000269|PubMed:11485571, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:26980435}. |
| Mouse PG classification | NA |
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