| Gene Information | |
|---|---|
| Gene Name | AK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 239 |
| Protein Names | Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed] |
| Target Name | adenylate kinase 2, mitochondrial |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000004455 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P54819 |
| Gene Card | AK2 |
| Uniprot ID | P54819 |
| Pfam | PF05191 |
| In ASD | no |
| Allosteric Prediction | yes (0.64262605) |
| Ortholog in Animals | Alpaca_ AK2 ( ortholog_one2one ) GuineaPig_ AK2 ( ortholog_one2one ) Macaque_ AK2 ( ortholog_one2one ) Mouse_ Ak2 ( ortholog_one2one ) Rat_ Ak2 ( ortholog_one2many ) Rat_ AABR07059925.1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | CMPK1, AK5, AK1, AK7, AK3, AK9, AK8, AK4, AK4P3 |
| Tissue | NA |
| Tissue Specificity | Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level). {ECO:0000269|PubMed:19043417}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2C9Y (X-ray 2.10A ) |
| DBSNP | rs267606648 rs267606643 rs12116440 |
| Subcellular location [CC] | Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03168}. |
| Mouse PG classification | NA |
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