| Gene Information | |
|---|---|
| Gene Name | AIFM3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 605 |
| Protein Names | Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000183773 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q96NN9 |
| Gene Card | AIFM3 |
| Uniprot ID | Q96NN9 |
| Pfam | PF07992; PF14759; PF00355 |
| In ASD | no |
| Allosteric Prediction | no (-1.284702403) |
| Ortholog in Animals | Alpaca_ AIFM3 ( ortholog_one2many ) GuineaPig_ AIFM3 ( ortholog_one2one ) Macaque_ AIFM3 ( ortholog_one2one ) Mouse_ Aifm3 ( ortholog_one2one ) Pig_ AIFM3 ( ortholog_one2one ) Rat_ Aifm3 ( ortholog_one2one ) Rabbit_ AIFM3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TXNRD3, AIFM1, PYROXD1, DLD, TXNRD2, TXNRD1, GSR |
| Tissue | brain, colon |
| Tissue Specificity | Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level). {ECO:0000269|PubMed:15764604}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.078428(Mouse);0.005276(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5O9V (X-ray 2.20A ) 6QRM (X-ray 2.30A ) 6SJZ (X-ray 2.00A ) 6SK3 (X-ray 2.70A ) 6SK8 (X-ray 1.87A ) 6SKJ (X-ray 2.80A ) |
| DBSNP | rs61356271 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:15764604}. Note=Does not translocate to the nucleus upon induction of apoptosis. |
| Mouse PG classification | NA |
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