| Gene Information | |
|---|---|
| Gene Name | BRSK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 736 |
| Protein Names | Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) |
| Target Name | br serine/threonine kinase 2 |
| Target Type | Literature-reported target |
| Gene Age | 1292 ( ENSG00000174672 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IWQ3 |
| Gene Card | BRSK2 |
| Uniprot ID | Q8IWQ3 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.190575999) |
| Ortholog in Animals | Dog_ BRSK2 ( ortholog_one2one ) GuineaPig_ BRSK2 ( ortholog_one2one ) Macaque_ BRSK2 ( ortholog_one2one ) Mouse_ Brsk2 ( ortholog_one2one ) Pig_ BRSK2 ( ortholog_one2one ) Rat_ Brsk2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TSSK6, SNRK, SIK2, SIK3, NIM1K, NUAK2, TSSK2, TSSK4, SIK1, PRKAA2, NUAK1, BRSK1, HUNK, PRKAA1, TSSK1B, MELK, TSSK3 |
| Tissue | brain, pancreas |
| Tissue Specificity | Detected in pancreas islets (at protein level). {ECO:0000269|PubMed:22798068}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin. |
| Mouse PG classification | NA |
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