| Gene Information | |
|---|---|
| Gene Name | TRIM63 |
| Organism | Homo sapiens (Human) |
| Gene Length | 353 |
| Protein Names | E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000158022 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q969Q1 |
| Gene Card | TRIM63 |
| Uniprot ID | Q969Q1 |
| Pfam | PF00643; PF13445 |
| In ASD | no |
| Allosteric Prediction | no (-0.172496044) |
| Ortholog in Animals | Alpaca_ TRIM63 ( ortholog_one2one ) Dog_ TRIM63 ( ortholog_one2one ) GuineaPig_ TRIM63 ( ortholog_one2one ) Macaque_ TRIM63 ( ortholog_one2one ) Mouse_ Trim63 ( ortholog_one2one ) Pig_ TRIM63 ( ortholog_one2one ) Rat_ Trim63 ( ortholog_one2one ) Rabbit_ TRIM63 ( ortholog_one2one ) |
| Ohnologs | TRIM55 |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39 |
| Tissue | heart, skeletal.muscle, artery, left.atrium, left.ventricle, pulmonary.valve, tongue |
| Tissue Specificity | Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris. {ECO:0000269|PubMed:11243782, ECO:0000269|PubMed:11283016, ECO:0000269|PubMed:11679633, ECO:0000269|PubMed:12107412}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2D8U (NMR - ) 3DDT (X-ray 1.90A ) 4M3L (X-ray 2.10A ) |
| DBSNP | rs762015648 rs758754060 rs529429430 rs1338320582 rs142601731 rs376414719 rs2275950 rs201397530 rs202001619 |
| Subcellular location [CC] | Cytoplasm. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. {ECO:0000250}. |
| Mouse PG classification | NA |
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