| Gene Information | |
|---|---|
| Gene Name | AIF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 147 |
| Protein Names | Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Protein G1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000204472 ) 3 ( ENSG00000206428 ) 3 ( ENSG00000234836 ) 3 ( ENSG00000235588 ) 3 ( ENSG00000235985 ) 3 ( ENSG00000237727 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P55008 |
| Gene Card | AIF1 |
| Uniprot ID | P55008 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.380524003) |
| Ortholog in Animals | Alpaca_ AIF1 ( ortholog_one2one ) Dog_ AIF1 ( ortholog_one2one ) GuineaPig_ AIF1 ( ortholog_one2one ) Macaque_ AIF1 ( ortholog_one2one ) Mouse_ Aif1 ( ortholog_one2one ) Pig_ AIF1 ( ortholog_one2one ) Rat_ Aif1 ( ortholog_one2one ) Rabbit_ AIF1 ( ortholog_one2one ) |
| Ohnologs | AIF1L |
| Paralogs | AIF1L |
| Tissue | NA |
| Tissue Specificity | Detected in T-lymphocytes and peripheral blood mononuclear cells. {ECO:0000269|PubMed:16049345}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2D58 (X-ray 1.90A ) 2G2B (NMR - ) |
| DBSNP | rs2736182 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70200}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O70200}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70200}; Cytoplasmic side {ECO:0000250|UniProtKB:O70200}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70200}. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. {ECO:0000250|UniProtKB:O70200}. |
| Mouse PG classification | NA |
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