| Gene Information | |
|---|---|
| Gene Name | ORAI1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 301 |
| Protein Names | Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A) |
| Target Name | calcium-release activated calcium channel |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000276045 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96D31 |
| Gene Card | ORAI1 |
| Uniprot ID | Q96D31 |
| Pfam | PF07856 |
| In ASD | yes |
| Allosteric Prediction | yes (0.800273682) |
| Ortholog in Animals | Alpaca_ ORAI1 ( ortholog_one2one ) Dog_ ORAI1 ( ortholog_one2one ) GuineaPig_ ORAI1 ( ortholog_one2one ) Macaque_ ORAI1 ( ortholog_one2one ) Mouse_ Orai1 ( ortholog_one2one ) Pig_ ORAI1 ( ortholog_one2one ) Rat_ Orai1 ( ortholog_one2one ) Rabbit_ ORAI1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ORAI2, ORAI3 |
| Tissue | NA |
| Tissue Specificity | Expressed in naive CD4 and CD8 T cells (at protein level) (PubMed:26956484). Expressed at similar levels in naive and effector T helper cells (PubMed:20354224). {ECO:0000269|PubMed:20354224, ECO:0000269|PubMed:26956484}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2MAK (NMR - ) 4EHQ (X-ray 1.90A ) |
| DBSNP | rs118203993 rs786204796 rs1555324111 rs3741596 rs587777528 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16582901, ECO:0000269|PubMed:16645049, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:20887894, ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:26956484, ECO:0000269|PubMed:27185316, ECO:0000269|PubMed:28058752, ECO:0000269|PubMed:28219928}; Multi-pass membrane protein {ECO:0000269|PubMed:16582901, ECO:0000269|PubMed:16645049, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:24351972}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8BWG9}; Multi-pass membrane protein {ECO:0000269|PubMed:19249086}. Note=Isoform beta is more mobile in the plasma membrane (PubMed:23307288). Colocalizes with STIM1 at the cell membrane (PubMed:27185316). {ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:27185316}. |
| Mouse PG classification | NA |
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