| Gene Information | |
|---|---|
| Gene Name | AHRR |
| Organism | Homo sapiens (Human) |
| Gene Length | 701 |
| Protein Names | Aryl hydrocarbon receptor repressor (AhR repressor) (AhRR) (Class E basic helix-loop-helix protein 77) (bHLHe77) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000063438 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | A9YTQ3 |
| Gene Card | AHRR |
| Uniprot ID | A9YTQ3 |
| Pfam | PF00010; PF00989 |
| In ASD | no |
| Allosteric Prediction | no (-0.272814213) |
| Ortholog in Animals | Alpaca_ PDCD6 ( ortholog_one2one ) Dog_ AHRR ( ortholog_one2one ) GuineaPig_ AHRR ( ortholog_one2one ) Macaque_ AHRR ( ortholog_one2one ) Mouse_ Ahrr ( ortholog_one2one ) Pig_ AHRR ( ortholog_one2one ) Rat_ Ahrr ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AHR |
| Tissue | testis |
| Tissue Specificity | Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary. {ECO:0000269|PubMed:11835227, ECO:0000269|PubMed:14672759, ECO:0000269|PubMed:18172554}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5Y7Y (X-ray 2.40A ) |
| DBSNP | rs35008248 rs2292596 rs2303738 rs34453673 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17980155}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:17980155}. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment. |
| Mouse PG classification | NA |
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