Gene Information
Gene NameAHCYL2
OrganismHomo sapiens (Human)
Gene Length611
Protein NamesAdenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.13.2.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000158467 )
Evolutionary StageCellular_organisms
AlphaFoldDBQ96HN2
Gene CardAHCYL2
Uniprot IDQ96HN2
PfamPF05221; PF00670
In ASDno
Allosteric Predictionno (-0.105054754)
Ortholog in AnimalsAlpaca_ AHCYL2 ( ortholog_one2one )
Alpaca_ AHCYL2 ( ortholog_one2many )
Dog_ AHCYL2 ( ortholog_one2one )
GuineaPig_ AHCYL2 ( ortholog_one2one )
Macaque_ AHCYL2 ( ortholog_one2one )
Mouse_ Ahcyl2 ( ortholog_one2one )
Pig_ AHCYL2 ( ortholog_one2one )
Rat_ Ahcyl2 ( ortholog_one2one )
Rabbit_ AHCYL2 ( ortholog_one2one )
OhnologsAHCYL1
ParalogsAHCYL1, AHCY
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.032633(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3GVP  (X-ray  2.25A 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000250|UniProtKB:A6QLP2, ECO:0000250|UniProtKB:Q68FL4}. Microsome {ECO:0000250|UniProtKB:Q68FL4}. Note=Associates with membranes when phosphorylated, probably through interaction with ITPR1. {ECO:0000250|UniProtKB:Q68FL4}.
Mouse PG classificationNA
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