| Gene Information | |
|---|---|
| Gene Name | AHCY |
| Organism | Homo sapiens (Human) |
| Gene Length | 432 |
| Protein Names | Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) |
| Target Name | adenosylhomocysteinase |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000101444 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P23526 |
| Gene Card | AHCY |
| Uniprot ID | P23526 |
| Pfam | PF05221; PF00670 |
| In ASD | yes |
| Allosteric Prediction | yes (1.258078444) |
| Ortholog in Animals | Alpaca_ AHCY ( ortholog_one2one ) GuineaPig_ AHCY ( ortholog_one2one ) Macaque_ AHCY ( ortholog_one2one ) Mouse_ Ahcyl ( ortholog_one2many ) Mouse_ Ahcy ( ortholog_one2many ) Pig_ AHCY ( ortholog_one2one ) Rabbit_ AHCY ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AHCYL2, AHCYL1 |
| Tissue | testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.034783(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A7A (X-ray 2.80A ) 1LI4 (X-ray 2.01A ) 3NJ4 (X-ray 2.50A ) 4PFJ (X-ray 2.30A ) 4PGF (X-ray 2.59A ) 4YVF (X-ray 2.70A ) 5W49 (X-ray 2.40A ) 5W4B (X-ray 2.65A ) |
| DBSNP | rs13043752 rs369428934 rs773162208 rs755222515 rs121918608 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Mouse PG classification | NA |
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